GSK172981 is a potent antagonist of the tachykinin NK3 receptor, demonstrating pKi values of 7.7 and 7.8 for human and native guinea pig NK3 receptors, respectively. This compound exhibits brain penetrance and is primarily utilized in research focused on schizophrenia, providing valuable insights into neurokinin signaling pathways and their implications in psychiatric disorders.
GSK172981 is a potent antagonist of the tachykinin NK3 receptor, demonstrating pKi values of 7.7 and 7.8 for human and native guinea pig NK3 receptors, respectively. This compound exhibits brain penetrance and is primarily utilized in research focused on schizophrenia, providing valuable insights into neurokinin signaling pathways and their implications in psychiatric disorders.
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