Fig. 1 · Structure
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GSK2220691
Cat. No.
A68753
CAS
1206619-37-5
TRPV4 Inhibitor
GSK2220691 is a potent antagonist of the transient receptor potential vanilloid 4 (TRPV4) channel. This compound effectively inhibits pulmonary edema induced by GSK1016790 and reduces HCl-induced increases in key mediators such as vascular endothelial growth factor (VEGF), keratinocyte-derived chemokine (KC; CXCL1), and granulocyte colony-stimulating factor (GCSF). GSK2220691 serves as a valuable tool for investigating TRPV4-related pathways and therapeutic applications in respiratory disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1206619-37-5 |
| Applications | TRPV4 Inhibitor |
| Formula | C32H33N5O3 |
| Molecular Weight | 535.64 |
| SMILES | O=C(N[C@@H](C(C)(C)C)C(N1[C@](C2)([H])CN(C(C3=CC=C(C4=CC=CC=C4)C=N3)=O)[C@]2([H])C1)=O)C5=CC6=C(N5)C=CC=C6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.