Fig. 1 · Structure
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GSK2332255B
Cat. No.
A68861
CAS
1366233-41-1
TRPC3/TRPC6 Antagonist
GSK2332255B is a highly selective antagonist of TRPC3 and TRPC6 channels, exhibiting IC50 values of 5 nM and 4 nM, respectively, for rat TRPC3 and TRPC6. This compound demonstrates over 100-fold selectivity for TRPC3 and TRPC6 compared to other calcium-permeable channels. GSK2332255B is valuable for research applications investigating the role of TRPC channels in various physiological and pathological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1366233-41-1 |
| Applications | TRPC3/TRPC6 Antagonist |
| Formula | C18H19ClFN3O3S |
| Molecular Weight | 411.88 |
| SMILES | O=C(C1=C(Cl)SC(NC2=C(F)C=C(OCO3)C3=C2)=N1)N4C(C)C(C)CCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.