Fig. 1 · Structure
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GSK5852
NS5B Inhibitor
GSK5852 is a selective inhibitor of the HCV NS5B polymerase, exhibiting an IC50 value of 50 nM. This compound demonstrates potent antiviral activity against hepatitis C virus, with EC50 values of 3.0 nM for genotype 1a (GT1a) and 1.7 nM for genotype 1b (GT1b). GSK5852 is valuable for research applications focused on the development of therapeutics for hepatitis C and in studies aiming to understand viral replication mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1331942-30-3 |
| Applications | NS5B Inhibitor |
| Formula | C27H25BF2N2O6S |
| Molecular Weight | 554.37 |
| Synonyms | GSK2485852 |
| SMILES | FC1=CC(CN(C2=CC3=C(C=C2C4CC4)C(C(NC)=O)=C(C5=CC=C(C=C5)F)O3)S(C)(=O)=O)=CC=C1B(O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.