Fig. 1 · Structure
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GSK778 hydrochloride
BET BD1 Inhibitor
GSK778 hydrochloride is a selective inhibitor that targets the BD1 bromodomain of BET proteins, demonstrating potent activity with IC50 values of 75 nM for BRD2 BD1, 41 nM for both BRD3 BD1 and BRD4 BD1, and 143 nM for BRDT BD1. This compound is valuable for research into the regulatory roles of BET proteins in transcriptional processes and has potential applications in cancer therapy and epigenetic studies. GSK778 hydrochloride serves as a critical tool for investigating the therapeutic possibilities of modulating BET protein interactions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2863657-79-6 |
| Applications | BET BD1 Inhibitor |
| Formula | C30H34ClN5O3 |
| Molecular Weight | 548.08 |
| Synonyms | iBET-BD1 hydrochloride |
| SMILES | CC1=NOC(C)=C1C2=C(OC[C@@H]3CNCC3)C=C4C5=C(N=C(COC)N5[C@H](C)C6=CC=CC=C6)C=NC4=C2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.