Fig. 1 · Structure
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GSK8175
NS5B Inhibitor
GSK8175 is a non-nucleoside inhibitor targeting the NS5B polymerase of hepatitis C virus (HCV). This sulfonamide-N-benzoxaborole analog demonstrates low in vivo clearance across various preclinical models and exhibits broad-spectrum activity against HCV replicons. It serves as a valuable tool for research into HCV replication and antiviral therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1423007-82-2 |
| Applications | NS5B Inhibitor |
| Formula | C27H23BClFN2O6S |
| Molecular Weight | 568.81 |
| Synonyms | GSK2878175 |
| SMILES | O=C(C1=C(C(C=C2)=CC=C2F)OC3=CC(N(C4=CC(Cl)=C5C(COB5O)=C4)[S](C)(=O)=O)=C(C6CC6)C=C13)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.