Fig. 1 · Structure
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H2N-PEG2-CH2COOH
PROTAC Linker
H2N-PEG2-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimera) synthesis. This compound serves as a versatile connector enabling the conjugation of target proteins to E3 ligase ligands, facilitating targeted protein degradation. Its application in the development of PROTACs supports research into novel therapeutic strategies for modulating protein levels in various diseases, including cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 134978-97-5 |
| Applications | PROTAC Linker |
| Formula | C6H13NO4 |
| Molecular Weight | 163.17 |
| SMILES | O=C(O)COCCOCCN |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.