Fig. 1 · Structure
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(-)-Halofantrine
Antimalarial Agent
(-)-Halofantrine is an effective antimalarial agent targeting the malignant malaria parasite Plasmodium falciparum, particularly against multidrug-resistant strains. This compound demonstrates varied pharmacokinetic parameters in rat models, influenced by the route of administration, which distinguishes it from its isomers. It serves as a valuable tool in malaria research and may facilitate the development of new treatment strategies for resistant malaria infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 66051-76-1 |
| Applications | Antimalarial Agent |
| Formula | C26H30Cl2F3NO |
| Molecular Weight | 500.42 |
| Synonyms | (-)-SKF-102886 free base; (-)-WR-171669 |
| SMILES | OC(CCN(CCCC)CCCC)C1=CC2=C(Cl)C=C(Cl)C=C2C3=CC(C(F)(F)F)=CC=C31.[Rotation (-)] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.