Fig. 1 · Structure
Documents & Downloads
Halofuginone lactate
Prolyl-tRNA Synthetase Inhibitor
Halofuginone lactate is a competitive inhibitor of prolyl-tRNA synthetase, exhibiting a Ki value of 18.3 nM. This compound specifically inhibits type-I collagen synthesis, making it valuable in the study of osteoarthritis by modulating TGF-β activity. Additionally, Halofuginone lactate acts as a potent pulmonary vasodilator, promoting Kv channel activation while blocking various calcium channels. Its diverse biological activities encompass anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects, facilitating its application in multiple areas of biomedical research.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 82186-71-8 |
| Applications | Prolyl-tRNA Synthetase Inhibitor |
| Formula | C19H23BrClN3O6 |
| Molecular Weight | 504.76 |
| Synonyms | RU-19110 lactate |
| SMILES | OC(C(O)C)=O.O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.