Fig. 1 · Structure
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HBF-0259
HBsAg Secretion Inhibitor
HBF-0259 is a potent and selective inhibitor of hepatitis B virus surface antigen (HBsAg) secretion, demonstrating an EC50 of 1.5 μM in HepG2.2.15 cell lines. This compound specifically targets HBsAg release without impacting HBV DNA synthesis, making it a valuable tool for studying hepatitis B virus pathogenesis and potential therapeutic interventions. Its unique mechanism can facilitate research into the modulation of HBV surface protein levels in liver cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 957011-15-3 |
| Applications | HBsAg Secretion Inhibitor |
| Formula | C16H12Cl2FN5 |
| Molecular Weight | 364.20 |
| SMILES | ClC1=CC=C(C2N=C3N(NN=N3)C(C4=C(F)C=CC=C4Cl)C2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.