Fig. 1 · Structure
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HBV-IN-31
cccDNA Inhibitor
HBV-IN-31 is a potent inhibitor of covalently closed circular DNA (cccDNA), demonstrating significant anti-HBV activity with an IC50 value of 0.13 µM for hepatitis B surface antigen (HBsAg). This compound effectively impedes cell growth, making it a valuable tool for research applications focused on chronic hepatitis B virus infection and cccDNA-related mechanisms. Researchers may utilize HBV-IN-31 to explore pathways associated with HBV replication and potentially develop therapeutic strategies targeting cccDNA.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2413192-95-5 |
| Applications | cccDNA Inhibitor |
| Formula | C23H18ClNO6 |
| Molecular Weight | 439.85 |
| SMILES | N#CC1=C(OCCOC2CC(C2)C(O)=O)C=CC(C(OC3=C4C=CC=C3Cl)=CC4=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.