Fig. 1 · Structure
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HBX 28258
USP7 Inhibitor
HBX 28258 is a selective inhibitor of ubiquitin-specific protease 7 (USP7), demonstrating an IC50 of 22.6 μM. By covalently binding to the cysteine residue at position 223 in the USP7 catalytic core, HBX 28258 effectively inhibits its deubiquitinating activity. This results in the degradation of MDM2 protein and subsequent activation of the p53 tumor suppressor pathway. This compound is valuable for research investigating the regulation of protein stability and the role of USP7 in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1426544-54-8 |
| Applications | USP7 Inhibitor |
| Formula | C26H30ClN3O |
| Molecular Weight | 435.99 |
| SMILES | O=C(C1=CC2=C(N=C3C(CCCC3)=C2Cl)C=C1)NCCCN(CC)CC4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.