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HDAC-IN-96

HDAC Inhibitor

HDAC-IN-96 is a selective inhibitor of histone deacetylases 1 and 2 (HDAC1/2), exhibiting IC50 values of 457.1 nM and 433.7 nM, respectively. This compound demonstrates significant cytotoxicity against various hematological tumor cell lines, including RS4;11, K562, RPMI-8226, and U266, with IC50 values between 2.11 and 5.35 μM. HDAC-IN-96 has been shown to induce apoptosis and cause S phase arrest in cancer cells, making it a valuable tool for research in hematological malignancies such as acute lymphoblastic leukemia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3055552-13-8
Applications	HDAC Inhibitor
Formula	C₂₇H₂₂FN₅O₅
Molecular Weight	515.49
SMILES	O=C(C1=CC=C(C=C1)CNC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)NC5=CC=C(C=C5N)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.