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Fig. 1 · Structure
Cat. No.
A13945
CAS No.
1447-88-7
Formula
C16H12O6
Mol. Weight
300.26

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Hispidulin

Cat. No. A13945 CAS 1447-88-7

Pim-1 inhibitor

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 EC50 7.3 μM Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay [PMID: 24955889]
Huh-7 CC50 > 50 μM Cytotoxicity against human Huh7.5.1 cells by MTT assay [PMID: 22445328]
Huh-7 EC50 36.3 μM Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay [PMID: 22445328]
MDCK CC50 172.46 μM Cytotoxicity against MDCK cells by MTT assay [PMID: 18640042]
MOLM-13 IC50 6.4 μM Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by MTT assay [PMID: 33026809]
MOLM-13 IC50 7 μM Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay [PMID: 33393294]
MV4-11 IC50 6.8 μM Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay [PMID: 33393294]
MV4-11 IC50 8.2 μM Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTT assay [PMID: 33026809]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1447-88-7
Applications Pim-1 inhibitor
Formula C16H12O6
Molecular Weight 300.26
Synonyms Dinatin
SMILES
O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(OC)C(O)=C13

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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