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HIV-1 inhibitor-58

Antiviral Agent

HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor targeting the HIV-1 virus. It effectively inhibits both wild-type strain IIIB and NNRTI-resistant variants, including K103N and E138K, with an EC50 of less than 50 nM in MT-4 cells. Additionally, it exhibits inhibitory activity against CYP2C9 and CYP2C19, with IC50 values of 2.06 μM and 1.91 μM, respectively. This compound is suitable for research related to HIV infection and antiviral therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3034064-68-8
Applications	Antiviral Agent
Formula	C₂₆H₂₄N₆O₂
Molecular Weight	452.51
SMILES	CC1=CC(C#N)=CC(C)=C1OC2=C3CN(CCC3=NC(NC4=CC=C(C=C4)C#N)=N2)C(CC)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.