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Homouridine

MMP-2 Inhibitor

Homouridine is an uridine analogue that acts as an MMP-2 inhibitor, exhibiting an IC50 of 150 μM for compound I. This compound demonstrates significant biological activity through its ability to inhibit TNF-α binding to the TNF-αR1, making it valuable for research applications focused on inflammatory responses and extracellular matrix remodeling. Homouridine serves as a vital intermediate in the synthesis of MMP-2 inhibitors, facilitating studies in cancer and tissue repair mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	30685-57-5
Applications	MMP-2 Inhibitor
Formula	C₁₀H₁₄N₂O₆
Molecular Weight	258.23
SMILES	O[C@@H]1[C@H](O)[C@@H](CCO)O[C@H]1N(C(N2)=O)C=CC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.