HPK1-IN-37

Catalog No.: A65780
MAP4K1/HPK1 Inhibitor
HPK1-IN-37 is a selective inhibitor of MAP4K1/HPK1, demonstrating an IC50 of 3.7 nM. Its potent inhibitory activity makes it a valuable tool for investigating HPK1-related disorders, including various cancer types. Researchers can utilize HPK1-IN-37 to elucidate the role of HPK1 in signal transduction pathways and therapeutic interventions.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHPK1-IN-37 is a selective inhibitor of MAP4K1/HPK1, demonstrating an IC50 of 3.7 nM. Its potent inhibitory activity makes it a valuable tool for investigating HPK1-related disorders, including various cancer types. Researchers can utilize HPK1-IN-37 to elucidate the role of HPK1 in signal transduction pathways and therapeutic interventions.
Product Information
Catalog NumA65780
FormulaC27H35N7O4
Molecular Weight521.61
CAS Number2766481-68-7
SMILESCN(CC1)CCC1N(N=C2)C=C2OC(N=C3C4=CC(C5(O)COC5)=CC(N6[C@@H](CCC6)CO)=C4)=C(N=C3)N
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