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HPK1-IN-46

HPK1 Inhibitor

HPK1-IN-46 is a selective inhibitor of HPK1, demonstrating an IC50 value of 1.1 nM. This compound effectively inhibits SLP76 phosphorylation mediated by HPK1, resulting in the reversal of T-cell inhibition and an enhancement of anti-tumor immunity. HPK1-IN-46 is valuable in immunotherapy research for tumors, particularly in exploring T-cell regulatory mechanisms and tumor microenvironment interactions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2810880-82-9
Applications	HPK1 Inhibitor
Formula	C₂₅H₂₅FN₆O
Molecular Weight	444.50
SMILES	FC1=CC=CC(OC)=C1C2=CC3=C(C=NN3C4=CC=CC(N5CC6N(C(CC6)C5)C)=N4)C=N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.