HPK1-IN-54 is a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1), significantly enhancing T cell activation and proliferation. With an IC50 value of 2.67 nM, it demonstrates over 100-fold selectivity against the MAP4K family and over 300-fold selectivity for other kinases. This compound exhibits potent antitumor effects, evidenced by strong efficacy in a CT26 murine colon cancer model and the ability to synergize with anti-PD-1 therapies. HPK1-IN-54 offers a valuable tool for research in immunotherapy applications.
HPK1-IN-54 is a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1), significantly enhancing T cell activation and proliferation. With an IC50 value of 2.67 nM, it demonstrates over 100-fold selectivity against the MAP4K family and over 300-fold selectivity for other kinases. This compound exhibits potent antitumor effects, evidenced by strong efficacy in a CT26 murine colon cancer model and the ability to synergize with anti-PD-1 therapies. HPK1-IN-54 offers a valuable tool for research in immunotherapy applications.
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