Fig. 1 · Structure
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Hydralazine
DNA Methyltransferase Inhibitor
Hydralazine is a potent DNA methyltransferase inhibitor that effectively crosses the blood-brain barrier. It reactivates silenced tumor suppressor genes through DNA demethylation, while also demonstrating vasodilatory effects and neuroprotective activities. Key biological effects include inhibition of NOS-2 (iNOS) and COX-2, leading to reduced nitric oxide and prostaglandin E2 production, as well as the scavenging of reactive oxygen species and suppression of macrophage activation. Hydralazine has applications in research related to hypertension, various cancers, spinal cord injury, and the mechanisms underlying inflammatory pain.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 86-54-4 |
| Applications | DNA Methyltransferase Inhibitor |
| Formula | C8H8N4 |
| Molecular Weight | 160.18 |
| SMILES | N/N=C1NN=CC2=C\1C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.