Hyrtiosal is a potent inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN), exhibiting an IC50 value of 9.60-0.86 μM. By specifically binding to the Ser17, Trp19, and Lys34 residues on the NTD, Hyrtiosal effectively disrupts the interaction between HIV-1 viral DNA and integrase, thus hindering the formation of the pre-integrated complex essential for viral replication. This compound is valuable for research focused on discovering and developing novel anti-HIV therapeutics.
Hyrtiosal is a potent inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN), exhibiting an IC50 value of 9.60-0.86 μM. By specifically binding to the Ser17, Trp19, and Lys34 residues on the NTD, Hyrtiosal effectively disrupts the interaction between HIV-1 viral DNA and integrase, thus hindering the formation of the pre-integrated complex essential for viral replication. This compound is valuable for research focused on discovering and developing novel anti-HIV therapeutics.
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