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Form	MW
Hyzetimibe This page	421.44
(E)-Hyzetimibe	421.44

Hyzetimibe

cholesterol absorption inhibitor

Hyzetimibe is a cholesterol absorption inhibitor that effectively reduces the intestinal uptake of cholesterol and phytosterols. This compound demonstrates a favorable safety profile in animal studies, achieving a maximum tolerated dose of 2000 mg/kg in rats and 500 mg/kg in rhesus monkeys. Research applications include studies on lipid metabolism and the evaluation of therapeutic strategies for hypercholesterolemia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1266548-74-6
Applications	cholesterol absorption inhibitor
Formula	C₂₅H₂₁F₂NO₃
Molecular Weight	421.44
Synonyms	HS-25
SMILES	OC/C(C1=CC=C(C=C1)F)=C\C[C@@H]2[C@](C3=CC=C(C=C3)O)([H])N(C4=CC=C(C=C4)F)C2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.