IACS-4759

Catalog No.: A38702
MTH1 Inhibitor
IACS-4759 is a potent and selective inhibitor of MTH1 (MutT homolog 1), with an IC50 value of 0.6 nM. This compound exhibits significant anti-cancer activity by disrupting the repair of damaged nucleotides, thereby inducing metabolic stress in cancer cells. IACS-4759 is useful for research applications focused on cancer metabolism and the development of targeted cancer therapies.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionIACS-4759 is a potent and selective inhibitor of MTH1 (MutT homolog 1), with an IC50 value of 0.6 nM. This compound exhibits significant anti-cancer activity by disrupting the repair of damaged nucleotides, thereby inducing metabolic stress in cancer cells. IACS-4759 is useful for research applications focused on cancer metabolism and the development of targeted cancer therapies.
Product Information
Catalog NumA38702
FormulaC10H17N3O2
Molecular Weight211.26
CAS Number1884209-99-7
SMILESOCC(C)(C)COC1=NC(N)=NC=C1C
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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