IAXO-101 iodide is a specific blocker of TLR4/CD14 signaling. This compound effectively inhibits the innate immune pathway mediated by CD14, demonstrating key biological activities such as enhancing intracortical microelectrode recording capabilities in murine models. Additionally, IAXO-101 iodide has been shown to partially alleviate fetal growth restriction and placental vascular damage, while reducing levels of the inflammatory cytokine TNF-α in pregnant mice with malaria infections. It serves as a valuable research tool for studying gestational malaria and other inflammatory disorders.
IAXO-101 iodide is a specific blocker of TLR4/CD14 signaling. This compound effectively inhibits the innate immune pathway mediated by CD14, demonstrating key biological activities such as enhancing intracortical microelectrode recording capabilities in murine models. Additionally, IAXO-101 iodide has been shown to partially alleviate fetal growth restriction and placental vascular damage, while reducing levels of the inflammatory cytokine TNF-α in pregnant mice with malaria infections. It serves as a valuable research tool for studying gestational malaria and other inflammatory disorders.
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