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CRBN modulator
In Stock
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| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| MM1.S | IC50 | 13 nM | Antiproliferative activity against human MM1S cells measured after 168 hrs by CellTiter96 Aqueous non-radioactive cell proliferation assay | [PMID: 31125896] |
| MV4-11 | IC50 | > 20000 nM | Antiproliferative activity against human MV411 cells measured after 168 hrs by CellTiter96 Aqueous non-radioactive cell proliferation assay | [PMID: 31125896] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1323403-33-3 |
| Applications | CRBN modulator |
| Formula | C25H27N3O5 |
| Molecular Weight | 449.5 |
| SMILES | O=C([C@@H](N(CC1=C2C=CC=C1OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)CC5)NC5=O |
| Solvent | Reported Solubility |
|---|---|
| DMSO | 77 mg/mL (171.3 mM) |
| Water | Insoluble |
| Ethanol | 6 mg/mL (13.35 mM) |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
