Icenticaftor is an orally active potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel, demonstrating EC50 values of 79 nM and 497 nM for the F508del and G551D CFTR mutations, respectively. This compound is valuable for research focused on chronic obstructive pulmonary disease (COPD) and cystic fibrosis, facilitating the study of disease mechanisms and potential therapeutic strategies.
Icenticaftor is an orally active potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel, demonstrating EC50 values of 79 nM and 497 nM for the F508del and G551D CFTR mutations, respectively. This compound is valuable for research focused on chronic obstructive pulmonary disease (COPD) and cystic fibrosis, facilitating the study of disease mechanisms and potential therapeutic strategies.
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