Fig. 1 · Structure
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Icerguastat Carbonate
PPP1R15A Inhibitor
Icerguastat Carbonate is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A), specifically designed to block eIF2α dephosphorylation. By inhibiting this process, Icerguastat Carbonate enhances the cellular protective response, making it a valuable tool in studies of cellular stress mechanisms. Its anti-prion properties further extend its applicability in neurodegenerative research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1883549-35-6 |
| Applications | PPP1R15A Inhibitor |
| Formula | C9H11ClN4O3 |
| Molecular Weight | 258.66 |
| Synonyms | Sephin1 Carbonate; IFB-088 Carbonate |
| SMILES | ClC1=C(C=CC=C1)/C=N/NC(N)=N.OC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.