Fig. 1 · Structure
Documents & Downloads
ICI 198583
Thymidylate Synthase Inhibitor
ICI 198583 is a potent inhibitor of thymidylate synthase (TS), exhibiting a Ki value of 10 nM against both mouse and human TS. It acts as a substrate for folylpolyglutamate synthetase (FPGS) with a Km of 40 μM, demonstrating dose-dependent and persistent inhibition of TS activity in vivo. This compound is valuable for research applications in leukemia and other related studies targeting nucleotide synthesis pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 112887-62-4 |
| Applications | Thymidylate Synthase Inhibitor |
| Formula | C25H24N4O6 |
| Molecular Weight | 476.48 |
| SMILES | O=C(CC[C@H](NC(C1=CC=C(C=C1)N(CC#C)CC2=CC3=C(C=C2)NC(C)=NC3=O)=O)C(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.