Idebenone-13C,d3 is a deuterium and carbon-13 labeled derivative of Idebenone, a potent mitochondrial protectant. It demonstrates neuroprotective effects and is relevant for studying neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Idebenone exhibits a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid, with an IC50 of 16.65 μM, and induces apoptotic cell death in SHSY-5Y human dopaminergic neuroblastoma cells. Additionally, it readily penetrates the blood-brain barrier, enhancing its potential in neurological research.
Idebenone-13C,d3 is a deuterium and carbon-13 labeled derivative of Idebenone, a potent mitochondrial protectant. It demonstrates neuroprotective effects and is relevant for studying neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Idebenone exhibits a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid, with an IC50 of 16.65 μM, and induces apoptotic cell death in SHSY-5Y human dopaminergic neuroblastoma cells. Additionally, it readily penetrates the blood-brain barrier, enhancing its potential in neurological research.
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