Fig. 1 · Structure
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Idetrexed trisodium
Thymidylate Synthase Inhibitor
Idetrexed trisodium is a potent inhibitor of thymidylate synthase (TS) with a Ki of 1.2 nM. This compound is selectively transported into tumors that overexpress the alpha-folate receptor (α-FR), making it particularly relevant for research in ovarian cancer and other folate receptor-positive malignancies. It serves as a valuable tool for studying TS inhibition and exploring therapeutic strategies in cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1097638-00-0 |
| Applications | Thymidylate Synthase Inhibitor |
| Formula | C32H30N5Na3O10 |
| Molecular Weight | 713.58 |
| Synonyms | BGC 945 trisodium; ONX 0801 trisodium; CB 300945 trisodium |
| SMILES | O=C(N[C@H](C(O[Na])=O)CCC(N[C@@H](C(O[Na])=O)CCC(O[Na])=O)=O)C1=CC=C(N([C@H]2CCC3=C2C=C4C(NC(CO)=NC4=O)=C3)CC#C)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.