Documents & Downloads

Idetrexed

Thymidylate Synthase Inhibitor

Idetrexed is a potent inhibitor of thymidylate synthase (TS) with a Ki of 1.2 nM. This compound demonstrates selective transport into α-folate receptor (α-FR)-overexpressing tumors, making it particularly relevant for research in ovarian cancer. Idetrexed is utilized in studies aimed at elucidating the mechanisms of TS inhibition and its therapeutic potential in cancer treatment.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	501332-69-0
Applications	Thymidylate Synthase Inhibitor
Formula	C₃₂H₃₃N₅O₁₀
Molecular Weight	647.63
Synonyms	BGC 945; ONX-0801; CB 300945
SMILES	C#CCN(C1=CC=C(C=C1)C(N[C@H](C(O)=O)CCC(N[C@@H](C(O)=O)CCC(O)=O)=O)=O)[C@@H]2C3=CC(C(N=C(N4)CO)=O)=C4C=C3CC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.