Fig. 1 · Structure
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IHMT-MST1-39
MST Inhibitor
IHMT-MST1-39 is a potent, orally active inhibitor of the MST kinases, demonstrating IC50 values of 42 nM for MST1, 109 nM for MST2, 286 nM for MST3, and 159 nM for MST4. This compound activates the AMPK signaling pathway in liver cells and reduces apoptosis in pancreatic β-cells. IHMT-MST1-39 is valuable for research focusing on type 1 diabetes (T1D) and type 2 diabetes (T2D), facilitating a deeper understanding of metabolic disorders and potential therapeutic approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2414484-01-6 |
| Applications | MST Inhibitor |
| Formula | C20H18F2N6O3S |
| Molecular Weight | 460.46 |
| SMILES | O=C1N(C)C2=CN=C(NC3=CC=C(S(=O)(N)=O)C=C3)N=C2N(C1C4=C(F)C=CC=C4F)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.