Fig. 1 · Structure
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II-B08
SHP2 Inhibitor
II-B08 is a reversible, noncompetitive inhibitor of SHP2, exhibiting an IC50 of 5.5 μM. This compound selectively inhibits SHP2 with reduced activity against SHP1 and PTP1B, demonstrating IC50 values of 15.7 μM and 14.3 μM, respectively. II-B08 is primarily utilized in cancer research to investigate the role of SHP2 signaling in tumorigenesis and therapeutic resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1143579-78-5 |
| Applications | SHP2 Inhibitor |
| Formula | C33H27N5O4 |
| Molecular Weight | 557.60 |
| SMILES | O=C(C1=CC2=C(N(C)C(C3=CC=CC=C3)=C2C4=CN(CCC(NC5=CC=C(C6=CC=CC=C6)C=C5)=O)N=N4)C=C1O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.