Fig. 1 · Structure
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IIIM-1270
NLRP3 Inflammasome Inhibitor
IIIM-1270 is a selective NLRP3 inflammasome inhibitor that effectively reduces the release of IL-1β in mouse macrophages (J774A.1 cells) with an IC50 of 3.5 μM. This compound significantly lowers the protein expression levels of mature IL-1β, making it a valuable tool for investigations into inflammatory pathways. IIIM-1270 is ideal for research applications focused on understanding the role of the NLRP3 inflammasome in various disease models related to inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 4818-19-3 |
| Applications | NLRP3 Inflammasome Inhibitor |
| Formula | C12H11NO2S |
| Molecular Weight | 233.29 |
| SMILES | CC1=CC=C(/C=C2SC(NC/2=O)=O)C(C)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.