Fig. 1 · Structure
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IK-930
TEAD Inhibitor
IK-930 is a potent and orally active inhibitor of TEAD transcription factors, exhibiting an EC50 value of less than 0.1 µM. This compound effectively disrupts the interaction between TEAD and its co-activators, thereby hindering TEAD-dependent gene transcription. IK-930 has significant implications for research in cancer biology and regenerative medicine, particularly in studies focusing on the Hippo signaling pathway and its role in cellular growth and differentiation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2563892-44-2 |
| Applications | TEAD Inhibitor |
| Formula | C19H19F3N4O2S |
| Molecular Weight | 424.44 |
| SMILES | O=S(NC)(C1=CC(C2=CN(C)C=N2)=C(NCC3=CC=C(C(F)(F)F)C=C3)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.