Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
BCL6 inhibitors and degraders act on B-cell lymphoma 6 (BCL6), a transcriptional repressor in B cells. The BCL6 gene was first identified through chromosomal alterations in diffuse large B-cell lymphoma (DLBCL), and BCL6 is required for germinal center B cells. A small molecule that blocks BCL6 repressor activity was shown to kill DLBCL cells in vitro and in vivo, which made the protein a research target in lymphoma. Listed inhibitors include FX1 and BI-3812, while BI-3802 and the proteolysis-targeting chimera (PROTAC) ARV-393 lower BCL6 protein levels. The section also holds molecular glues such as TCIP3 and building blocks for degrader synthesis.
