Toll-like Receptors

Cat. No.

A26220

CAS No.

1246298-62-3

Kdo2-Lipid A ammonium

Kdo2-Lipid A ammonium is a selective TLR4 activator known for its potent endotoxin activity comparable to that of lipopolysaccharide (LPS). It effectively stimulates the release of pro-inflammatory mediators, including tumor necrosis factor (TNF) and prostaglandin E2 (PGE2). This compound is widely utilized in immunological research to investigate TLR4 signaling pathways and the associated inflammatory responses.

Cat. No.

A35364

CAS No.

2380231-86-5

TLR7 agonist 6

TLR7 Agonist 6 is a potent TLR7 activator with an EC50 value of 1.0 nM. This compound modulates immune responses by activating Toll-like receptor 7, which is crucial for recognizing viral RNA and activating downstream signaling pathways. TLR7 Agonist 6 is valuable for research in immunology, particularly in studies exploring antiviral responses and the development of therapeutic strategies for infectious diseases.

Cat. No.

A35372

CAS No.

1149339-78-5

TMX-201

TMX-201 is a TLR7 ligand-phospholipid conjugate that functions as a potent immune stimulator. Its activity enhances immune responses, making it a valuable tool in cancer research, particularly in studies of breast cancer and melanoma. TMX-201 is useful for exploring TLR7-mediated pathways and their implications in tumor immunology.

Cat. No.

A35385

CAS No.

2412937-64-3

TLR8 agonist 2

TLR8 Agonist 2 is a selective activator of Toll-like receptor 8, exhibiting a potent EC50 of 3 nM for human TLR8. This compound demonstrates minimal activity against human TLR7, with an EC50 of 33.33 μM. TLR8 Agonist 2 is valuable for investigating immune responses and therapeutic applications in the modulation of innate immunity.

Cat. No.

A35386

CAS No.

2567953-47-1

TLR7/8 agonist 7

TLR7/8 agonist 7 is a novel activator of Toll-like receptors 7 and 8, crucial components in the immune response. This compound stimulates various immune cell types, facilitating immune activation and promoting the synthesis of immune-stimulating antibody conjugate (ISAC) molecules. TLR7/8 agonist 7 is a valuable tool for investigating immune pathways and developing immunotherapeutic strategies.

Cat. No.

A35430

CAS No.

937769-72-7

ORN 02

ORN 02 is a synthetic single-stranded U-rich RNA that acts as a Toll-like receptor 8 (TLR8) activator. This reagent consists of six repeats of the UUAU sequence motif, which enhances its ability to stimulate TLR8 signaling. ORN 02 is useful in research applications focused on immune response modulation and the study of RNA-based therapeutics. Its role in TLR8 activation positions it as an important tool for investigating innate immunity and potential therapeutic strategies.

Cat. No.

A35483

CAS No.

2832199-53-6

TLR7 agonist 15

TLR7 Agonist 15 is a potent TLR7 activator that exhibits an EC50 of 18 nM. This compound effectively stimulates the activation of mouse macrophages and human peripheral blood mononuclear cells (hPBMCs) at low nanomolar concentrations. It holds potential applications in immunology research, particularly in studies focused on innate immune responses and antiviral mechanisms.

Cat. No.

A35487

CAS No.

943316-60-7

CCL-34

CCL-34 is a potent Toll-like receptor 4 (TLR4) activator that effectively promotes dendritic cell maturation by significantly increasing CD83 expression and IL-12p70 production in a dose-dependent manner. This compound enhances the allostimulatory capacity of dendritic cells, leading to increased proliferation and IFN-γ secretion in naive CD4+CD45+RA+ T cells. Additionally, CCL-34 has demonstrated its capacity to boost antigen presentation in murine models with doxorubicin-treated colorectal cancer cells, making it valuable for research into immune stimulation and therapeutic strategies.

Cat. No.

A35489

CAS No.

3099165-43-9

TLR7 agonist 33

TLR7 Agonist 33 is a potent activator of Toll-like receptor 7 (TLR7) with an EC50 of 1 nM. This compound exhibits significant immunostimulatory activity, making it suitable for cancer research and therapeutic applications targeting TLR signaling pathways. Its ability to enhance innate immune responses positions TLR7 Agonist 33 as a valuable tool in studying the role of TLR7 in tumor immunity and potential cancer treatments.

Cat. No.

A35496

CAS No.

2832199-45-6

TLR7 agonist 14

TLR7 Agonist 14 (compound 17b) is a potent activator of Toll-like receptor 7 (TLR7) with an EC50 value of 18 nM. This compound effectively stimulates the activation of mouse macrophages and human peripheral blood mononuclear cells (hPBMCs) at low nanomolar concentrations. Its significant biological activity makes it a valuable tool for research applications focused on immune modulation and inflammation pathways.

Cat. No.

A35512

CAS No.

15366-29-7

Creatine ethyl ester

Synonyms: CEE

Creatine ethyl ester (CEE) serves as an activator of Toll-like receptors (TLRs), specifically TLR2, TLR3, TLR4, and TLR7. This compound is notable for its short-term capability to upregulate these receptors, making it a valuable tool in immunological research. Its role in modulating TLR activity may provide insights into innate immune responses and their implications in various disease contexts.