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IFNAR

IFNAR modulators act on the type I interferon receptor (IFNAR), which binds interferon alpha and beta. The receptor has two chains: IFNAR1 was cloned as a functional human interferon alpha receptor, and IFNAR2 was later characterized as the ligand-binding chain. Mice lacking type I interferon signaling are highly susceptible to viral infection. Products here include RO8191, a small-molecule IFNAR agonist, and IFN alpha-IFNAR-IN-1 hydrochloride, which blocks the ligand-receptor interaction. The section also lists 2',3'-cGAMP, an upstream inducer of type I interferon, and IRF5-IN-1, which targets the interferon regulatory factor 5 (IRF5) transcription factor.

1 Item

  • CP-28888
    Cat. No.
    A64873
    CAS No.
    69938-75-6

    CP-28888

    Synonyms: CP 28888-27

    CP-28888 is an interferon alpha/beta receptor (IFNAR) inducer that enhances the immune response by promoting the production of type I interferons. It exhibits greater potency in murine models, making it a valuable tool for studying immune modulation and antiviral responses in preclinical research. Despite its limited efficacy in human trials and lack of antirhinovirus activity, CP-28888 remains a relevant compound in the investigation of therapeutic approaches targeting interferon pathways.

    In stock View Details
    1 mg
    $235.00
    5 mg
    $590.00
    All 5 sizes

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