IFNAR

Cat. No.

A64859

CAS No.

1465774-27-9

2'2'-cGAMP

2'2'-cGAMP is a synthetic cyclic dinucleotide (CDN) that targets the STING (Stimulator of Interferon Genes) pathway, playing a crucial role in the immune response. It effectively induces the production of interferon-beta (IFN-β), a key cytokine involved in antiviral defense. While 2'2'-cGAMP exhibits a weaker affinity for STING compared to 2'3'-cGAMP, it demonstrates a stronger interaction than other CDNs, making it valuable for research in immunology and therapeutic applications related to immune modulation.

Cat. No.

A64872

CAS No.

2978670-53-8

Antitumor agent-210

Antitumor agent-210 is an NK cell activator known for enhancing the activation and degranulation of natural killer (NK) cells. It exerts a modest proliferative effect on NK92 cells, significantly increasing their cytotoxicity against tumor cells. This compound promotes the release of key cytokines, including granzyme B, perforin, and IFN-γ, and has demonstrated efficacy in reducing lung metastatic lesions in murine models. Antitumor agent-210 is a valuable reagent for researching melanoma lung metastasis and other cancer-related immunological studies.

Cat. No.

A64873

CAS No.

69938-75-6

CP-28888

Synonyms: CP 28888-27

CP-28888 is an interferon alpha/beta receptor (IFNAR) inducer that enhances the immune response by promoting the production of type I interferons. It exhibits greater potency in murine models, making it a valuable tool for studying immune modulation and antiviral responses in preclinical research. Despite its limited efficacy in human trials and lack of antirhinovirus activity, CP-28888 remains a relevant compound in the investigation of therapeutic approaches targeting interferon pathways.