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MHC

Major histocompatibility complex (MHC) research products include peptide antigens that MHC molecules present to T cells. Class I molecules display peptides from cytosolic proteins to cytotoxic T cells, whereas class II molecules present to helper T cells. In 1974 virus-specific T cell killing was shown to require a shared MHC haplotype, known as MHC restriction. The 1987 crystal structure of human leukocyte antigen A2 (HLA-A2) revealed a peptide-binding groove between two α-helices. The chicken ovalbumin (OVA) epitope SIINFEKL is offered as OVA Peptide(257-264) TFA, a trifluoroacetate salt. It binds the mouse class I molecule H-2Kb and is used to stimulate ovalbumin-specific cytotoxic T cells. OVA (55-62) is a second ovalbumin peptide presented by H-2Kb in mouse T cell studies.

1 Item

  • Glatiramer acetate
    Cat. No.
    B18104
    CAS No.
    147245-92-9

    Glatiramer acetate

    Glatiramer acetate is a synthetic analogue of myelin basic protein that functions primarily as an immune modulator for the treatment of multiple sclerosis. Its mechanism involves inhibiting experimental autoimmune encephalomyelitis (EAE) by competing with myelin antigens for binding to MHC molecules, which subsequently modulates T cell response. Additionally, glatiramer acetate promotes the induction of T helper 2 (Th2) cells, which migrate to the central nervous system and facilitate localized immunosuppression. This compound serves as a valuable tool for research into autoimmune disorders and therapeutics for multiple sclerosis.

    In stock View Details
    2 mg
    $30.00
    5 mg
    $50.00
    All 6 sizes

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