Nitric Oxide Signaling (NOS)

Cat. No.

A17843

CAS No.

540-69-2

Formic acid ammonium

Synonyms: Ammonium formate

Formic acid ammonium serves as an ammonium salt derivative of formic acid, functioning as a nitric oxide/cyclic guanosine monophosphate (NO/cGMP) activator. This compound activates NO/cGMP signaling in endothelial cells and inhibits calcium ion influx in vascular smooth muscle cells, promoting vasomotor relaxation. Additionally, formic acid ammonium inhibits cytochrome C oxidase, disrupting the electron transport chain and resulting in ATP depletion. This reagent also finds utility as a feed additive, where it can lower the feed pH, inhibit the growth of pathogenic microorganisms such as Escherichia coli and Salmonella, thereby enhancing the shelf life of the feed.

Cat. No.

A18204

CAS No.

621-72-7

Bendazol

Bendazol is a nitric oxide synthase activator that plays a significant role in vascular smooth muscle relaxation. Its primary biological activity involves the dilation of blood vessels, leading to reduced peripheral resistance and improved blood circulation, making it useful in the study of antihypertensive effects. Bendazol has been shown to inhibit myopia development in rabbit models and positively influences kidney function by enhancing NO synthase activity in nephrogenic hypertension models. Additionally, this compound affects sexual behavior and spermatogenesis in male rats, contributing to its relevance in reproductive health research.

Cat. No.

A20485

CAS No.

2482-00-0

Agmatine sulfate

Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

Cat. No.

A20754

CAS No.

450348-85-3

AVE-3085

AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment.

Cat. No.

A24137

CAS No.

607723-33-1

Lobeglitazone

Lobeglitazone is a novel thiazolidinedione-class compound and an orally active dual agonist of peroxisome proliferator-activated receptors (PPARs), with EC₅₀ values of 137.4 nM for PPARγ and 546.3 nM for PPARα. In addition to its metabolic effects, Lobeglitazone functions as an inhibitor of multiple pro-inflammatory and pro-fibrotic signaling pathways, including ERK, JNK, Smad, and NF-κB. Lobeglitazone exhibits a broad range of pharmacological activities, including anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic effects. These properties make it a promising candidate for therapeutic research in metabolic syndrome, type 2 diabetes, cardiovascular disease, and fibrosis-related conditions.

Cat. No.

A24240

CAS No.

763108-62-9

Lobeglitazone sulfate

Lobeglitazone sulfate is a novel thiazolidinedione and an orally active agonist of peroxisome proliferator-activated receptors (PPARs), with EC50 values of 137.4 nM for PPARγ and 546.3 nM for PPARα. It also acts as an inhibitor of the ERK/JNK/Smad/NF-κB signaling pathways. Lobeglitazone sulfate exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic activities, supporting its potential in the treatment of metabolic and inflammatory diseases.

Cat. No.

A44003

CAS No.

94356-26-0

Piceatannol 3'-O-glucoside

Synonyms: Quzhaqigan

Piceatannol 3'-O-glucoside is a potent activator of endothelial nitric oxide (NO) synthase that functions by inhibiting arginase activity. Demonstrating IC50 values of 11.22 μM and 11.06 μM for arginase I and arginase II, respectively, this compound is valuable for research focused on vascular biology and endothelial function. Its role in enhancing NO production makes it an important tool for studying cardiovascular health and related signaling pathways.

Cat. No.

A65070

CAS No.

6779-87-9

7,8-Dihydro-L-biopterin

7,8-Dihydro-L-biopterin serves as a nitric oxide synthase (NOS) uncoupling inducer and is capable of crossing the blood-brain barrier. As a reduced, non-conjugated pteridine and the primary metabolite of 4-amino-tetrahydro-L-biopterin, it promotes the conversion of NOS to a superoxide-producing form, elevating oxidative stress levels, particularly in the renal outer medulla, and triggering apoptosis. This compound's sensitivity to superoxide dismutase (SOD) inhibition makes it valuable for research into salt-sensitive hypertension, traumatic brain injury, and neurodegenerative diseases.

Cat. No.

A65107

CAS No.

133565-48-7

L-Hydroxy arginine dihydrochloride

L-Hydroxy arginine dihydrochloride is a substrate for nitric oxide synthase (NOS), playing a crucial role in the production of nitric oxide from L-arginine. This compound is utilized in biochemical research to investigate the enzymatic pathways of NO synthesis and its physiological implications. Its applications extend to studies exploring vascular function, signal transduction, and the impact of nitric oxide in various biological systems.

Cat. No.

A65290

CAS No.

37466-21-0

L-Arginine arginine

L-Arginine is a substrate for endothelial nitric oxide synthase (eNOS), facilitating the production of nitric oxide (NO). This compound acts as a potent vasodilator, influencing vascular tone and blood flow. It is commonly utilized in research applications related to cardiovascular studies and may also be employed to induce experimental acute pancreatitis.