Nitric Oxide Signaling (NOS)

Cat. No.

A17843

CAS No.

540-69-2

Formic acid ammonium

Synonyms: Ammonium formate

Formic acid ammonium serves as an ammonium salt derivative of formic acid, functioning as a nitric oxide/cyclic guanosine monophosphate (NO/cGMP) activator. This compound activates NO/cGMP signaling in endothelial cells and inhibits calcium ion influx in vascular smooth muscle cells, promoting vasomotor relaxation. Additionally, formic acid ammonium inhibits cytochrome C oxidase, disrupting the electron transport chain and resulting in ATP depletion. This reagent also finds utility as a feed additive, where it can lower the feed pH, inhibit the growth of pathogenic microorganisms such as Escherichia coli and Salmonella, thereby enhancing the shelf life of the feed.

Cat. No.

A18204

CAS No.

621-72-7

Bendazol

Bendazol is a nitric oxide synthase activator that plays a significant role in vascular smooth muscle relaxation. Its primary biological activity involves the dilation of blood vessels, leading to reduced peripheral resistance and improved blood circulation, making it useful in the study of antihypertensive effects. Bendazol has been shown to inhibit myopia development in rabbit models and positively influences kidney function by enhancing NO synthase activity in nephrogenic hypertension models. Additionally, this compound affects sexual behavior and spermatogenesis in male rats, contributing to its relevance in reproductive health research.

Cat. No.

A20754

CAS No.

450348-85-3

AVE-3085

AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment.

Cat. No.

A44003

CAS No.

94356-26-0

Piceatannol 3'-O-glucoside

Synonyms: Quzhaqigan

Piceatannol 3'-O-glucoside is a potent activator of endothelial nitric oxide (NO) synthase that functions by inhibiting arginase activity. Demonstrating IC50 values of 11.22 μM and 11.06 μM for arginase I and arginase II, respectively, this compound is valuable for research focused on vascular biology and endothelial function. Its role in enhancing NO production makes it an important tool for studying cardiovascular health and related signaling pathways.