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Nitric Oxide Signaling (NOS)

Nitric oxide synthase (NOS) inhibitors and related tools act on the enzymes that make nitric oxide from L-arginine. NOS was first isolated from rat brain in 1990 and shown to require calmodulin for its activity. Three isoforms exist, neuronal, endothelial and inducible NOS (iNOS), the last expressed mainly in activated immune cells. 1400W dihydrochloride, described in 1997 as a slow, tight-binding iNOS inhibitor, and GW274150 are used for isoform-selective studies. L-NIO dihydrochloride is an arginine analog that inhibits several isoforms. Asymmetric dimethylarginine is an endogenous NOS inhibitor that accumulates in chronic renal failure. 2,4-Diamino-6-hydroxypyrimidine blocks GTP cyclohydrolase I, which limits synthesis of the NOS cofactor tetrahydrobiopterin.

3 Items

  • 7,8-Dihydro-L-biopterin
    Cat. No.
    A65070
    CAS No.
    6779-87-9

    7,8-Dihydro-L-biopterin

    7,8-Dihydro-L-biopterin serves as a nitric oxide synthase (NOS) uncoupling inducer and is capable of crossing the blood-brain barrier. As a reduced, non-conjugated pteridine and the primary metabolite of 4-amino-tetrahydro-L-biopterin, it promotes the conversion of NOS to a superoxide-producing form, elevating oxidative stress levels, particularly in the renal outer medulla, and triggering apoptosis. This compound's sensitivity to superoxide dismutase (SOD) inhibition makes it valuable for research into salt-sensitive hypertension, traumatic brain injury, and neurodegenerative diseases.

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    2 mg
    $25.00
    5 mg
    $35.00
    All 6 sizes
  • L-Hydroxy arginine dihydrochloride
    Cat. No.
    A65107
    CAS No.
    133565-48-7

    L-Hydroxy arginine dihydrochloride

    L-Hydroxy arginine dihydrochloride is a substrate for nitric oxide synthase (NOS), playing a crucial role in the production of nitric oxide from L-arginine. This compound is utilized in biochemical research to investigate the enzymatic pathways of NO synthesis and its physiological implications. Its applications extend to studies exploring vascular function, signal transduction, and the impact of nitric oxide in various biological systems.

    In stock View Details
    5 mg
    $165.00
    10 mg
    $270.00
    All 5 sizes
  • L-Arginine arginine
    Cat. No.
    A65290
    CAS No.
    37466-21-0

    L-Arginine arginine

    L-Arginine is a substrate for endothelial nitric oxide synthase (eNOS), facilitating the production of nitric oxide (NO). This compound acts as a potent vasodilator, influencing vascular tone and blood flow. It is commonly utilized in research applications related to cardiovascular studies and may also be employed to induce experimental acute pancreatitis.

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    Out of stock

    All 3 sizes

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