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PD-1-PD-L1

PD-1/PD-L1 inhibitors are research compounds that block binding between an inhibitory T cell receptor and its ligand. Programmed cell death protein 1 (PD-1) was first identified in 1992 as a gene induced in cell lines undergoing programmed cell death. Its ligand, programmed death-ligand 1 (PD-L1), is a B7 family protein whose binding to PD-1 inhibits T cell proliferation and cytokine secretion. This checkpoint limits T cell activation and is studied in immune tolerance, tumor immunology and chronic infection. Small molecules such as BMS-202 bind PD-L1 and induce its dimerization, which hides the surface that engages PD-1. The category lists BMS-1166, BMS-202 and PD-1-IN-1 as small-molecule tools, alongside the anti-PD-L1 antibody avelumab as a reference reagent.

1 Item

  • H-20
    Cat. No.
    A35694
    CAS No.
    3020015-02-2

    H-20

    H-20 is a potent PD-1 agonist that modulates immune responses by enhancing programmed cell death protein 1 signaling. This compound demonstrates significant biological activity in research related to chronic pain and immune regulation. Its applications extend to investigating the therapeutic potential of PD-1 activation in managing pain conditions and understanding the underlying mechanisms involved in chronic inflammatory responses.

    In stock View Details
    1 mg
    $70.00
    5 mg
    $180.00
    All 4 sizes

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