Fig. 1 · Structure
Documents & Downloads
IMP-1700
DNA Damage Potentiator
IMP-1700 is a potent DNA damage potentiator that effectively inhibits the bacterial SOS response to DNA damage. This compound significantly sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ciprofloxacin, exhibiting an EC50 of 5.9 nM. Additionally, IMP-1700 demonstrates antibacterial activity against various strains, including Escherichia coli K-12 BW25113, Staphylococcus aureus SH1000, and MRSA USA300 JE2, making it a valuable tool for research in antibiotic resistance and bacterial response to DNA damage.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1458674-25-3 |
| Applications | DNA Damage Potentiator |
| Formula | C25H22F4N4O3S |
| Molecular Weight | 534.53 |
| SMILES | O=C(O)C1=CN(C2=CC(=C(F)C=C2C1=O)N3CCN(C(=S)NC4=CC=C(C=C4)C(F)(F)F)CC3)C5CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.