Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain fused with human IgG1 Fc, serving as an IL-15 superagonist. This compound forms a complex with the IL-15 antibody Nogapendekin alfa, enhancing anti-CD20 monoclonal antibody-mediated natural killer (NK) cell activity and antibody-dependent cellular cytotoxicity (ADCC). Inbakicept significantly promotes degranulation and interferon-gamma (IFNγ) production in NK cells, making it a valuable tool for research in immunotherapy and cancer treatment strategies.
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain fused with human IgG1 Fc, serving as an IL-15 superagonist. This compound forms a complex with the IL-15 antibody Nogapendekin alfa, enhancing anti-CD20 monoclonal antibody-mediated natural killer (NK) cell activity and antibody-dependent cellular cytotoxicity (ADCC). Inbakicept significantly promotes degranulation and interferon-gamma (IFNγ) production in NK cells, making it a valuable tool for research in immunotherapy and cancer treatment strategies.
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