Incyclinide

Catalog No.: A17240

MMP inhibitor

Incyclinide

Incyclinide Chemical Structure

CAS NO. 15866-90-7

Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.

Availability: In stock

Package Price Qty
1 mg
$160.00
5 mg
$480.00
10 mg
$720.00
50 mg
$2,200.00
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Biological Activity

Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.93 mL 134.65 mL 269.29 mL
0.5 mM 5.39 mL 26.93 mL 53.86 mL
1 mM 2.69 mL 13.46 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL

*The above data is based on the productmolecular weight 371.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17240
Actions Inhibitor
CAS No. 15866-90-7
Formula C19H17NO7
M. Wt 371.34
Purity >98%
Synonyms CMT-3; CMT 3; CMT3; COL3; COL-3; COL 3
SMILES O=C(C1=C(O)C[[email protected]@](C[[email protected]@]2([H])C(C(C3=C(O)C=CC=C3C2)=O)=C4O)([H])[[email protected]@]4(O)C1=O)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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