Fig. 1 · Structure
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Indole-2-carboxylic acid
Lipid Peroxidation Inhibitor
Indole-2-carboxylic acid is an inhibitor of lipid peroxidation, functioning as a competitive antagonist of the glycine site on the NMDA receptor, with a Ki value of 15 μM. It selectively interrupts the enhancement of NMDA receptor activity by blocking glycine binding, which is crucial in various neurological disorders. Additionally, Indole-2-carboxylic acid inhibits the strand transfer activity of HIV-1 integrase by chelating magnesium ions at the enzyme's active site, allowing for impactful research applications in both neurobiology and virology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1477-50-5 |
| Applications | Lipid Peroxidation Inhibitor |
| Formula | C9H7NO2 |
| Molecular Weight | 161.16 |
| SMILES | O=C(C(N1)=CC2=C1C=CC=C2)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.