Fig. 1 · Structure
Documents & Downloads
Inecalcitol
VDR Agonist
Inecalcitol is a potent vitamin D receptor (VDR) agonist with a dissociation constant (Kd) of 0.53 nM, demonstrating a strong affinity for VDR. This unique vitamin D3 analog induces apoptotic pathways and exhibits significant anticancer activities. Additionally, Inecalcitol features an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for diverse biochemical studies and research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 163217-09-2 |
| Applications | VDR Agonist |
| Formula | C26H40O3 |
| Molecular Weight | 400.59 |
| Synonyms | TX 522 |
| SMILES | O[C@H]1C[C@H](O)C/C(C1)=C/C=C2[C@@]3([H])CC[C@H]([C@H](C)CC#CC(C)(O)C)[C@@]3(C)CCC/2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.