INI-4001 is a TLR7/8 agonist that modulates innate and adaptive immune responses by activating both murine TLR7 and human TLR7/TLR8 pathways. This compound enhances immunological responses, leading to increased IgG and neutralizing antibodies against Powassan virus (POWV) while concurrently reducing viral loads in multiple organs, including the brain and liver. INI-4001 also provides complete protection from lethal POWV challenges and promotes a Th1-biased immune response. It has demonstrated efficacy when used in combination with aluminum hydroxide and SARS-CoV-2 RBD antigen, making it valuable for research on Powassan virus infection and COVID-19 immunology.
INI-4001 is a TLR7/8 agonist that modulates innate and adaptive immune responses by activating both murine TLR7 and human TLR7/TLR8 pathways. This compound enhances immunological responses, leading to increased IgG and neutralizing antibodies against Powassan virus (POWV) while concurrently reducing viral loads in multiple organs, including the brain and liver. INI-4001 also provides complete protection from lethal POWV challenges and promotes a Th1-biased immune response. It has demonstrated efficacy when used in combination with aluminum hydroxide and SARS-CoV-2 RBD antigen, making it valuable for research on Powassan virus infection and COVID-19 immunology.
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